Our client, a leading pharmaceutical company, is hiring an Analytical Method Automation Sr. Associate Scientist, on a contract basis.
Job ID: 82689
Work Location:
Seattle, WA – 100% on site
Summary:
Seeking an Analytical Method Automation Sr. Associate Scientist to contribute to the development and implementation of novel immunoassays that enable rapid, unsupervised and robust characterization of cell therapy process intermediates during the manufacturing process. This candidate will work closely with lab automation engineers, analytical development and process development scientists to test and implement novel reagents to streamline sample preparation, data acquisition and data analysis workflow. The candidate will also work with the team to transition from manual to automated workflows as development progresses, characterizing method performance and robustness between the two modes. This candidate will support the qualification of the developed automated assay, ensuring method readiness for manufacturing implementation. This role provides a unique opportunity to screen and implement novel assay technologies to support near real-time CAR-T monitoring during manufacturing. A strong background in immunoassays, particularly flow cytometry development, will be needed.
Education/Experience:
- Bachelors degree in molecular or cellular biology, biomedical engineering, or related discipline
- 4 years of experience in cell-based assay development, specifically cell counting and flow-based assays
- Experience with method development and qualification
Knowledge/Skills:
- Previous experience with flow cytometry assay development for cell characterization, including panel design and sample preparation protocol development
- Knowledge of flow cytometry reagents and approaches to support automation and streamlining of methods
- Previous experience with in vitro culture of primary cells
- Highly motivated, detail oriented with the ability to multi-task
- Ability to work independently and as part of a team
- Strong organizational and time management skills
- Strong written, verbal and presentation skills
Responsibilities:
- Test commercially available reagents for assessment in novel flow cytometry methods.
- Plan method testing to support thorough screening of sample preparation parameters and their impact on data acquisition/analysis quality
- Support custom reagent testing and streamlining of analytical method to enable operator-free execution
- Execute analytical method qualification studies to demonstrate readiness for manufacturing implementation
- Analyze experiment data to identify trends, support decision making and determine next steps
- Prepare and present data on development progress, analytical method performance across sample types, comparability to existing methods where applicable
- Author technical documents such as method operating procedures, comparability and qualification protocols and reports.
- Collaboration and Communication:
- Communicate effectively with internal stakeholders to ensure alignment and transparency.
- Work with internal collaborators to support method transfer to other sites
Pay: $49-$50/hr